First of all, you question suggest you are working with NCS/NSO and this is really a place for ConfD users to interact with one another and share knowledge about ConfD.
That said, your question is about NETCONF and might be of interest to others: the answer is no.
The transport for NETCONF is SSH (or TLS) and both are sent over TCP. TCP guarantees reliable in-order delivery but there is no way for a sender to know when a client has read and understood a message (as opposed to when the message has been received and ACKed by the TCP/IP-stack in the receiving host).